{"id":228,"date":"2026-04-03T01:13:15","date_gmt":"2026-04-03T05:13:15","guid":{"rendered":"https:\/\/chemcenterbio.org\/?post_type=product&#038;p=228"},"modified":"2026-04-03T01:13:15","modified_gmt":"2026-04-03T05:13:15","slug":"isrib-1-gram-raw-powder","status":"publish","type":"product","link":"https:\/\/chemcenterbio.org\/?product=isrib-1-gram-raw-powder","title":{"rendered":"ISRIB 1 Gram Raw Powder"},"content":{"rendered":"<p><span class=\"citation-3449 citation-3450 citation-3451 citation-3452 citation-3453 citation-3454 citation-3455 citation-3456 citation-3457 citation-3458 citation-3459 citation-3460 citation-3461 citation-3462 citation-3463 citation-end-3463\">ISRIB (Integrated Stress Response Inhibitor) is a potent cognitive enhancer first discovered in 2013 by Carmela Sidrauski in the laboratory of Peter Walter at UCSF. It was identified through a high-throu<\/span><span class=\"citation-3449 citation-3450 citation-3451 citation-3452 citation-3453 citation-3454 citation-3455 citation-3456 citation-3457 citation-3458 citation-3459 citation-3460 citation-3461 citation-3462 citation-end-3462\">ghput screen for compounds that could maintain protein synthesis even under cellular stre<\/span><span class=\"citation-3449 citation-3450 citation-3451 citation-3452 citation-3453 citation-3454 citation-3455 citation-3456 citation-3457 citation-3458 citation-3459 citation-3460 citation-3461 citation-end-3461\">ss.<\/span><\/p>\n<p><span class=\"citation-3436 citation-3437 citation-3438 citation-3439 citation-3440 citation-3441 citation-3442 citation-3443 citation-3444 citation-3445 citation-3446 citation-3447 citation-3448 citation-end-3448\">How It Works<\/span><\/p>\n<p><span class=\"citation-3423 citation-3424 citation-3425 citation-3426 citation-3427 citation-3428 citation-3429 citation-3430 citation-3431 citation-3432 citation-3433 citation-3434 citation-3435 citation-end-3435\">ISRIB acts<\/span><span class=\"citation-3423 citation-3424 citation-3425 citation-3426 citation-3427 citation-3428 citation-3429 citation-3430 citation-3431 citation-3432 citation-3433 citation-3434 citation-end-3434\"> as a &#8220;molecular staple.&#8221; It binds to and stabilizes th<\/span><span class=\"citation-3423 citation-3424 citation-3425 citation-3426 citation-3427 citation-3428 citation-3429 citation-3430 citation-3431 citation-3432 citation-3433 citation-end-3433\">e eIF2B complex, which is a critical regulator of pro<\/span><span class=\"citation-3423 citation-3424 citation-3425 citation-3426 citation-3427 citation-3428 citation-3429 citation-3430 citation-3431 citation-3432 citation-end-3432\">tein synthesis. By stabilizing this complex, ISRIB reverses the inhibito<\/span><span class=\"citation-3423 citation-3424 citation-3425 citation-3426 citation-3427 citation-3428 citation-3429 citation-3430 citation-3431 citation-end-3431\">ry effects of eIF2\u03b1 phosphorylation, effectively &#8220;turnin<\/span><span class=\"citation-3423 citation-3424 citation-3425 citation-3426 citation-3427 citation-3428 citation-3429 citation-3430 citation-end-3430\">g back on&#8221; the cell\u2019s machinery for making ne<\/span><span class=\"citation-3423 citation-3424 citation-3425 citation-3426 citation-3427 citation-3428 citation-3429 citation-end-3429\">w proteins\u2014a process usually shut down during the Integrated Stress Re<\/span><span class=\"citation-3423 citation-3424 citation-3425 citation-3426 citation-3427 citation-3428 citation-end-3428\">sponse (ISR).<\/span><\/p>\n<p><span class=\"citation-3417 citation-3418 citation-3419 citation-3420 citation-3421 citation-3422 citation-end-3422\">Research Benefits (Rodent Studi<\/span><span class=\"citation-3417 citation-3418 citation-3419 citation-3420 citation-3421 citation-end-3421\">es)<\/span><\/p>\n<ul data-path-to-node=\"4\">\n<li><span class=\"citation-3412 citation-3413 citation-3414 citation-3415 citation-3416\">Memory Enhancement:<\/span><span class=\"citation-3412 citation-3413 citation-3414 citation-3415 citation-3416 citation-end-3416\"> Significant improvement<\/span><span class=\"citation-3412 citation-3413 citation-3414 citation-3415 citation-end-3415\">s in spatial and fear-conditioning memory.<\/span><\/li>\n<li><span class=\"citation-3408 citation-3409 citation-3410 citation-3411\">Brain Injury Recovery:<\/span><span class=\"citation-3408 citation-3409 citation-3410 citation-3411 citation-end-3411\"> Shown to restore cognitive function in mice weeks after traumatic brain injury (TB<\/span><span class=\"citation-3408 citation-3409 citation-3410 citation-end-3410\">I).<\/span><\/li>\n<li><span class=\"citation-3405 citation-3406 citation-3407\">Anti-Aging:<\/span><span class=\"citation-3405 citation-3406 citation-3407 citation-end-3407\"> Evidence suggests it can reverse age-related cognitive decline by restoring protein synthesis levels in the brain.<\/span><\/li>\n<li><span class=\"citation-3402 citation-3403 citation-3404\">Neuroprotection:<\/span><span class=\"citation-3402 citation-3403 citation-3404 citation-end-3404\"> Investigated for potential in treating ALS,<\/span><span class=\"citation-3402 citation-3403 citation-end-3403\"> prion disease, and other neurodegenerative conditions.<\/span><\/li>\n<\/ul>\n<p><span class=\"citation-3400 citation-3401 citation-end-3401\">Potential Side Effects<\/span><\/p>\n<p><span class=\"citation-3398 citation-3399 citation-end-3399\">In most rodent models, ISRIB is well-tolerated. However, research indicates tha<\/span><span class=\"citation-3398 citation-end-3398\">t the Integrated Stress Response is a natural defense mechanism; blocking it indefinitely or at extremely high doses (e.g., 5 mg\/kg\/da<\/span>y in specific disease models like Alzheimer&#8217;s) has been associated with increased mortality in some studies.<\/p>\n<p>Rodent Dosages<\/p>\n<p>Typical experimental dosages in mice range from 0.1 mg\/kg to 2.5 mg\/kg administered daily.<\/p>\n<p>Reconstitution &amp; Storage<\/p>\n<ul data-path-to-node=\"8\">\n<li>Reconstitution: Dissolve the powder in anhydrous DMSO (recommended concentration of 5-10 mg\/mL). Sonication or gentle warming (up to 60\u00b0C) may be required for full dissolution.<\/li>\n<li>Storage: Keep the dry powder at -20\u00b0C for long-term stability (up to 3 years). Once reconstituted in DMSO, store in small aliquots at -80\u00b0C for up to 1 year or -20\u00b0C for up to <span class=\"citation-3395 citation-3396 citation-3397 citation-end-3397\">3 months. Avoid repeated freeze-thaw cycles.<\/span><\/li>\n<\/ul>\n<p><span class=\"citation-3392 citation-3393 citation-3394 citation-end-3394\">Shipping &amp; Quality Assurance<\/span><\/p>\n<ul data-path-to-node=\"10\">\n<li><span class=\"citation-3389 citation-3390 citation-3391\">Purity:<\/span><span class=\"citation-3389 citation-3390 citation-3391\"> Comes with a legitimate Certificate of Analysis (COA) for the original batch confirming <\/span><span class=\"citation-3389 citation-3390 citation-3391\">99% purity<\/span><span class=\"citation-3389 citation-3390 citation-3391 citation-end-3391\">.<\/span><\/li>\n<li><span class=\"citation-3386 citation-3387 citation-3388\">Free Shipping:<\/span><span class=\"citation-3386 citation-3387 citation-3388\"> Ships direct from our Chinese manufacturer. Delivery takes <\/span><span class=\"citation-3386 citation-3387 citation-3388\">7-30 business days<\/span><span class=\"citation-3386 citation-3387 citation-3388 citation-end-3388\">.<\/span><\/li>\n<li><span class=\"citation-3383 citation-3384 citation-3385\">Tracking:<\/span><span class=\"citation-3383 citation-3384 citation-3385\"> Customers will receive a tracking number within <\/span><span class=\"citation-3383 citation-3384 citation-3385 citation-end-3385\">5 business days<\/span><span class=\"citation-3383 citation-3384 citation-end-3384\"> of order placement.<\/span><\/li>\n<li><span class=\"citation-3381 citation-3382\">Applications:<\/span><span class=\"citation-3381 citation-3382 citation-end-3382\"> This powder is suitable for research involving injection, oral, or intranasal administration,<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>ISRIB (Integrated Stress Response Inhibitor) is a cutting-edge research compound and potent cognitive enhancer. Known as a &#8220;molecular staple,&#8221; it works by stabilizing the eIF2B complex to maintain protein synthesis even during cellular stress. This mechanism has shown remarkable potential in rodent studies for reversing age-related cognitive decline, improving memory, and restoring brain function following traumatic injuries.<\/p>\n<p>Each batch of our raw powder is verified at 99% purity and includes a legitimate Certificate of Analysis (COA) for quality assurance.<\/p>\n<hr data-path-to-node=\"3\" \/>\n<p data-path-to-node=\"4\">Key Research Highlights<\/p>\n<ul data-path-to-node=\"5\">\n<li>Cognitive Enhancement: Supports significant improvements in spatial and fear-conditioning memory.<\/li>\n<li>Neuroprotection: Under investigation for its potential in treating ALS and other neurodegenerative conditions.<\/li>\n<li>Recovery Support: Shown to restore cognitive function in models of traumatic brain injury (TBI).<\/li>\n<li>Anti-Aging: Evidence suggests it can &#8220;turn back on&#8221; protein synthesis machinery to combat cognitive aging.<\/li>\n<\/ul>\n<hr data-path-to-node=\"6\" \/>\n<p data-path-to-node=\"7\">Storage &amp; Shipping<\/p>\n<ul data-path-to-node=\"8\">\n<li>Stability: Store dry powder at -20\u00b0C for up to 3 years.<\/li>\n<li>Shipping: Enjoy free shipping directly from the manufacturer (7-30 business days).<\/li>\n<li>Tracking: A tracking number will be provided within 5 business days of your order.<\/li>\n<\/ul>\n<blockquote data-path-to-node=\"9\"><p>Note: This product is intended for research applications including injection, oral, or intranasal administration.<\/p><\/blockquote>\n","protected":false},"featured_media":229,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[55,26,24,28],"product_tag":[61,63,60,23,58,57,64,56,62,54,50,21,20,59],"class_list":{"0":"post-228","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-als","7":"product_cat-anxiety-depression","8":"product_cat-concussion","9":"product_cat-dementia-alzheimers","10":"product_tag-als","11":"product_tag-anxiety","12":"product_tag-brain-injury","13":"product_tag-cognitive-enhancement","14":"product_tag-concussions","15":"product_tag-cte","16":"product_tag-fear","17":"product_tag-isrib","18":"product_tag-memory","19":"product_tag-neurodegeneration","20":"product_tag-neuroprotection","21":"product_tag-nootropic","22":"product_tag-peptides","23":"product_tag-tbi","25":"first","26":"instock","27":"shipping-taxable","28":"purchasable","29":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/chemcenterbio.org\/index.php?rest_route=\/wp\/v2\/product\/228","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chemcenterbio.org\/index.php?rest_route=\/wp\/v2\/product"}],"about":[{"href":"https:\/\/chemcenterbio.org\/index.php?rest_route=\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/chemcenterbio.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=228"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chemcenterbio.org\/index.php?rest_route=\/wp\/v2\/media\/229"}],"wp:attachment":[{"href":"https:\/\/chemcenterbio.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=228"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/chemcenterbio.org\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_brand&post=228"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/chemcenterbio.org\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_cat&post=228"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/chemcenterbio.org\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_tag&post=228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}